Crisera PN,  "The cytological implications of primary respiration", Medical
Hypotheses, Jan 2001; 56 (1): 40-51,

Abstract

Observing the macroscopic complexities of evolved species, the exceptional
continuity that occurs among different cells, tissues and organs to respond
coherently to the proper set of stimuli as a function of self/species
survival is appreciable. Accordingly, it alludes to a central rhythm that
resonates throughout the cell; nominated here as primary respiration (PR),
which is capable of binding and synchronizing a diversity of physiological
processes into a functional biological unity. Phylogenetically, it was
conserved as an indispensable element in the makeup of the subkingdom
Metazoan, since these species require a high degree of coordination among the
different cells that form their body. However, it does not preclude the
possibility of a basal rhythm to orchestrate the intricacies of cellular
dynamics of both prokaryotic and eukaryotic cells. In all probability, PR
emerges within the crucial organelles, with special emphasis on the DNA (5),
and propagated and transduced within the infrastructure of the cytoskeleton
as wave harmonics (49). Collectively, this equivalent vibration for the
subphylum Vertebrata emanates as craniosacral respiration (CSR), though its
expression is more elaborate depending on the development of the CNS.
Furthermore, the author suggests that the phenomenon of PR or CSR be
intimately associated to the basic rest/activity cycle (BRAC), generated by
concentrically localized neurons that possess auto-oscillatory properties and
assembled into a vital network (39). Historically, during
Protochordate-Vertebrate transition, this area circumscribes an archaic
region of the brain in which many vital biological rhythms have their source,
called hindbrain rhombomeres. Bass and Baker (2) propose that
pattern-generating circuits of more recent innovations, such as vocal,
electromotor, extensor muscle tonicity, locomotion and the extraocular
system, have their origin from the same Hox gene-specified compartments of
the embryonic hindbrain (rhombomeres 7 and 8) that produce rhythmically
active cardiac and thoracic respiratory circuits. Here, it implies that PR
could have been the first essential biological cadence that arose with the
earliest form of life, and has undergone a phylogenetic ascent to produce an
integrated multirhythmic organism of today. Finally, in its full
manifestation, the breathing DNA (1) of the zygote could project itself
throughout the cytoskeleton and modify the electromechanical properties of
the plasma lamella (26), establishing the primordial axial-voltage gradients
for the physiological control of development (53)